Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinesterase-Treated Mice
نویسندگان
چکیده
منابع مشابه
Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice.
Mice were administered anticholinesterase pesticides dichlorvos (DDVP) or methomyl (MET). Both DDVP and MET induced dose-dependent seizures and lethality in mice. The muscarinic antagonist atropine (ATR, 1.8 mg/kg) did not prevent seizures but diminished the lethality induced by DDVP or MET. The nicotinic antagonist mecamylamine (MEC, 1 mg/kg) affected neither DDVP-induced seizures nor DDVP- an...
متن کاملFrom anticholinesterase toxicity to Alzheimer's disease: important interactions of cholinergic and NMDA receptor systems.
The article highlighted in this issue is "Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinesterase-Treated Mice," by Andrzej Dekundy, Rafal M. Kaminski, and Waldemar A. Turski (pp. 289-295). It explores the relationship between cholinergic and N-methyl-D-aspartate (NMDA) receptors as mediators of anticholinesterase toxicity. The following review summarizes these ...
متن کاملTOXICOLOGICAL HIGHLIGHT From Anticholinesterase Toxicity to Alzheimer’s Disease: Important Interactions of Cholinergic and NMDA Receptor Systems
The article highlighted in this issue is “Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinesterase-Treated Mice,” by Andrzej Dekundy, Rafal M. Kaminski, and Waldemar A. Turski (pp. 289–295). It explores the relationship between cholinergic and N-methyl-D-aspartate (NMDA) receptors as mediators of anticholinesterase toxicity. The following review summarizes these ...
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متن کاملComparison of action of cholinergic and anticholinesterase agents in glaucoma
The cholinergic agents have the advantages of systemic safety, fewer undesirable local side effects, and usefulness in angle-closure and narrow-angle glaucoma. The powerful cholinesterase inhibitors, on the other hand, produce better diurnal reduction of intraocular pressure, require less frequent administration, and can control many cases whose pressures cannot be otherwise brought to heal. Ne...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2003
ISSN: 1096-0929
DOI: 10.1093/toxsci/kfg013